BOSTON -- Adam Eaton was given some unusual advice on what to do between at-bats in his first appearance as a designated hitter.

It must have worked. He made his time at the plate look easy.

Eaton, inserted as the DH because of a sore left shoulder, had three hits and drove in two runs to lift the Chicago White Sox to a 10-8 victory over the Boston Red Sox on Monday night.

"Being a DH, it's a little different," he said. "They told me to come back (into the clubhouse) to fold laundry, get out of the dugout, relax when you're not hitting."

It was the fifth straight win for the White Sox, coming off a four-game sweep at home over Cleveland.

Eaton had a triple, double and single to key Chicago's 15-hit night. He opened the game with his triple, sparking a four-run first.

"These guys have been swinging pretty good lately," manager Robin Ventura said. "We've been aggressive and we've been coming out in the first inning."

Boston's David Ortiz homered for the third time in two games, hitting a two-run shot after a career-best, seven-RBI night that included two three-run homers in a win Sunday.

Mookie Betts added three hits and two RBI for the Red Sox, who have lost 10 of 12.

Ortiz homered into the center-field bleachers, the 486th of his career, in the first, about 90 minutes after the club traded outfielder Shane Victorino to the Los Angeles Angels in a deal for a minor league infielder.

"It's very emotional, for more reasons than one. I set out, and as I said from day one, I wanted to come here and I wanted to finish ... my contract here," said Victorino, who broke down in a press conference after the game.

In a seesaw contest that saw both teams squander leads, the White Sox broke a 7-all tie in the seventh against Robbie Ross Jr. (0-1).

J.B. Shuck doubled leading off and scored on Tyler Flowers' single. One out later, Eaton hit an RBI single.

"Certainly the bullpen and offense won the game today," said starter John Danks, who gave up seven runs in 4 1/3 innings.

Danks didn't give up a run in his previous two starts, covering 12 2/3 innings.

Matt Albers (1-0) got five outs in scoreless relief. David Robertson pitched the ninth for his 22nd save.

Boston's Joe Kelly, making his second start after being demoted to the minors, gave up five runs -- four earned -- in 3 1/3 innings.

"He had a rough outing. A lot of elevated pitches in the strike zone," manager John Farrell said. "They were strikes, but the command within the strike zone was lacking. A lot of hard contact early."

Third baseman Tyler Saladino's second error, when he bounced a throw past first, allowed Boston to take a 7-6 edge, but the White Sox tied it on Eaton's RBI double.

Trailing 5-4 in the fourth, Boston scored twice to grab its first lead. Betts' RBI single tied it before Saladino booted Hanley Ramirez's bouncer with the bases loaded.

Boston's Ryan Hanigan had a passed ball that scored a run, tying it at 6.

The White Sox jumped ahead 4-0 in the first, scoring three before making an out. Eaton and Saladino opened the game with consecutive triples, Melky Cabrera had an RBI double and Shuck a run-scoring grounder. The fourth scored on Alexei Ramirez's double-play grounder.

TRAINER'S ROOM

White Sox: Eaton, who missed Sunday's win over Cleveland after he banged his throwing shoulder diving for a ball a day earlier, replaced slumping Adam LaRoche as the DH. He could return to center field Tuesday. "I did some throwing motion," Eaton said after the game. "I don't see why I wouldn't be back in there tomorrow."

Red Sox: Brock Holt (hyper-extended left knee) missed the game after coming out early Sunday night.

NICE COMPANY

Ortiz has 13 straight seasons with 20 or more homers with the Red Sox. The only other AL player to do it more was Babe Ruth, who had 15 with the New York Yankees from 1920-34.

PEDRO NIGHT

The Red Sox will retire Hall of Famer Pedro Martinez's No. 45 in a pregame ceremony before Tuesday's contest. It'll be the eighth Red Sox number retired -- the first of a pitcher.

UP NEXT

White Sox: RHP Jeff Samardzija (7-5) has been rumored in a handful of trades, but he's slated to start Tuesday.

Red Sox: LHP Wade Miley (8-8) looks to snap a four-game winless stretch.