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| Rank | JUGADOR | EQUIPO | JJ | JI | EL | H | D | CL | BB | P | G | P | SALV | HLD | BLSV | EFE |
| 1 | CC Sabathia | NYY | 34 | 34 | 230.0 | 197 | 96 | 86 | 67 | 197 | 19 | 8 | 0 | 0 | 0 | 3.37 |
| Felix Hernandez | SEA | 34 | 34 | 238.2 | 200 | 81 | 66 | 71 | 217 | 19 | 5 | 0 | 0 | 0 | 2.49 | |
| Justin Verlander | DET | 35 | 35 | 240.0 | 219 | 99 | 92 | 63 | 269 | 19 | 9 | 0 | 0 | 0 | 3.45 | |
| 4 | Roy Halladay | TOR | 32 | 32 | 239.0 | 234 | 82 | 74 | 35 | 208 | 17 | 10 | 0 | 0 | 0 | 2.79 |
| Josh Beckett | BOS | 32 | 32 | 212.1 | 198 | 99 | 91 | 55 | 199 | 17 | 6 | 0 | 0 | 0 | 3.86 | |
| Scott Feldman | TEX | 34 | 31 | 189.2 | 178 | 87 | 86 | 65 | 113 | 17 | 8 | 0 | 0 | 0 | 4.08 | |
| 7 | Zack Greinke | KAN | 33 | 33 | 229.1 | 195 | 64 | 55 | 51 | 242 | 16 | 8 | 0 | 0 | 0 | 2.16 |
| Joe Saunders | LAA | 31 | 31 | 186.0 | 202 | 102 | 95 | 64 | 101 | 16 | 7 | 0 | 0 | 0 | 4.60 | |
| Jered Weaver | LAA | 33 | 33 | 211.0 | 196 | 91 | 88 | 66 | 174 | 16 | 8 | 0 | 0 | 0 | 3.75 | |
| 10 | Scott Baker | MIN | 33 | 33 | 200.0 | 190 | 99 | 97 | 48 | 162 | 15 | 9 | 0 | 0 | 0 | 4.37 |
| Rank | JUGADOR | EQUIPO | JJ | JI | EL | H | D | CL | BB | P | G | P | SALV | HLD | BLSV | EFE |
| Jon Lester | BOS | 32 | 32 | 203.1 | 186 | 80 | 77 | 64 | 225 | 15 | 8 | 0 | 0 | 0 | 3.41 | |
| 12 | Andy Pettitte | NYY | 32 | 32 | 194.2 | 193 | 101 | 90 | 76 | 148 | 14 | 8 | 0 | 0 | 0 | 4.16 |
| Carl Pavano | CLE/MIN | 33 | 33 | 199.1 | 235 | 119 | 113 | 39 | 147 | 14 | 12 | 0 | 0 | 0 | 5.10 | |
| Rick Porcello | DET | 31 | 31 | 170.2 | 176 | 81 | 75 | 52 | 89 | 14 | 9 | 0 | 0 | 0 | 3.96 | |
| 15 | Kevin Millwood | TEX | 31 | 31 | 198.2 | 195 | 88 | 81 | 71 | 123 | 13 | 10 | 0 | 0 | 0 | 3.67 |
| A.J. Burnett | NYY | 33 | 33 | 207.0 | 193 | 99 | 93 | 97 | 195 | 13 | 9 | 0 | 0 | 0 | 4.04 | |
| Mark Buehrle | CHW | 33 | 33 | 213.1 | 222 | 97 | 91 | 45 | 105 | 13 | 10 | 0 | 0 | 0 | 3.84 | |
| Edwin Jackson | DET | 33 | 33 | 214.0 | 200 | 93 | 86 | 70 | 161 | 13 | 9 | 0 | 0 | 0 | 3.62 | |
| Jeff Niemann | TAM | 31 | 30 | 180.2 | 185 | 84 | 79 | 59 | 125 | 13 | 6 | 0 | 0 | 0 | 3.94 | |
| John Danks | CHW | 32 | 32 | 200.1 | 184 | 89 | 84 | 73 | 149 | 13 | 11 | 0 | 0 | 0 | 3.77 | |
| Rank | JUGADOR | EQUIPO | JJ | JI | EL | H | D | CL | BB | P | G | P | SALV | HLD | BLSV | EFE |
| Ricky Romero | TOR | 29 | 29 | 178.0 | 192 | 88 | 85 | 79 | 141 | 13 | 9 | 0 | 0 | 0 | 4.30 | |
| 22 | Tim Wakefield | BOS | 21 | 21 | 129.2 | 137 | 67 | 66 | 50 | 72 | 11 | 5 | 0 | 0 | 0 | 4.58 |
| John Lackey | LAA | 27 | 27 | 176.1 | 177 | 84 | 75 | 47 | 139 | 11 | 8 | 0 | 0 | 0 | 3.83 | |
| Gavin Floyd | CHW | 30 | 30 | 193.0 | 178 | 93 | 87 | 59 | 163 | 11 | 11 | 0 | 0 | 0 | 4.06 | |
| James Shields | TAM | 33 | 33 | 219.2 | 239 | 113 | 101 | 52 | 167 | 11 | 12 | 0 | 0 | 0 | 4.14 | |
| Nick Blackburn | MIN | 33 | 33 | 205.2 | 240 | 103 | 92 | 41 | 98 | 11 | 11 | 0 | 0 | 0 | 4.03 | |
| Matt Palmer | LAA | 40 | 13 | 121.1 | 105 | 55 | 53 | 55 | 69 | 11 | 2 | 0 | 0 | 0 | 3.93 | |
| Brett Anderson | OAK | 30 | 30 | 175.1 | 180 | 94 | 79 | 45 | 150 | 11 | 11 | 0 | 0 | 0 | 4.06 | |
| David Huff | CLE | 23 | 23 | 128.1 | 159 | 82 | 80 | 41 | 65 | 11 | 8 | 0 | 0 | 0 | 5.61 | |
| 30 | Jeremy Guthrie | BAL | 33 | 33 | 200.0 | 224 | 120 | 112 | 60 | 110 | 10 | 17 | 0 | 0 | 0 | 5.04 |
| Rank | JUGADOR | EQUIPO | JJ | JI | EL | H | D | CL | BB | P | G | P | SALV | HLD | BLSV | EFE |
| Scott Kazmir | LAA/TAM | 26 | 26 | 147.1 | 149 | 85 | 80 | 60 | 117 | 10 | 9 | 0 | 0 | 0 | 4.89 | |
| Kevin Slowey | MIN | 16 | 16 | 90.2 | 113 | 50 | 49 | 15 | 75 | 10 | 3 | 0 | 0 | 0 | 4.86 | |
| David Price | TAM | 23 | 23 | 128.1 | 119 | 72 | 63 | 54 | 102 | 10 | 7 | 0 | 0 | 0 | 4.42 | |
| Alfredo Aceves | NYY | 43 | 1 | 84.0 | 69 | 36 | 33 | 16 | 69 | 10 | 1 | 1 | 6 | 1 | 3.54 | |
| Trevor Cahill | OAK | 32 | 32 | 178.2 | 185 | 99 | 92 | 72 | 90 | 10 | 13 | 0 | 0 | 0 | 4.63 | |
| 36 | Jarrod Washburn | DET/SEA | 28 | 28 | 176.0 | 160 | 77 | 74 | 49 | 100 | 9 | 9 | 0 | 0 | 0 | 3.78 |
| Joba Chamberlain | NYY | 32 | 31 | 157.1 | 167 | 94 | 83 | 76 | 133 | 9 | 6 | 0 | 0 | 0 | 4.75 | |
| Tommy Hunter | TEX | 19 | 19 | 112.0 | 113 | 55 | 51 | 33 | 64 | 9 | 6 | 0 | 0 | 0 | 4.10 | |
| 39 | Vicente Padilla | TEX | 18 | 18 | 108.0 | 120 | 61 | 59 | 42 | 59 | 8 | 6 | 0 | 0 | 0 | 4.92 |
| Kyle Davies | KAN | 22 | 22 | 123.0 | 122 | 76 | 72 | 66 | 86 | 8 | 9 | 0 | 0 | 0 | 5.27 | |
Data provided by Elias Sports Bureau