| Pitcheo | ||||||||||||||||
| Rank | JUGADOR | EQUIPO | JJ | JI | EL | H | D | CL | BB | P | G | P | SALV | HLD | BLSV | EFE |
| 1 | Zack Greinke | KAN | 33 | 33 | 229.1 | 195 | 64 | 55 | 51 | 242 | 16 | 8 | 0 | 0 | 0 | 2.16 |
| 2 | Chris Carpenter | STL | 28 | 28 | 192.2 | 156 | 49 | 48 | 38 | 144 | 17 | 4 | 0 | 0 | 0 | 2.24 |
| 3 | Tim Lincecum | SFO | 32 | 32 | 225.1 | 168 | 69 | 62 | 68 | 261 | 15 | 7 | 0 | 0 | 0 | 2.48 |
| 4 | Felix Hernandez | SEA | 34 | 34 | 238.2 | 200 | 81 | 66 | 71 | 217 | 19 | 5 | 0 | 0 | 0 | 2.49 |
| 5 | Jair Jurrjens | ATL | 34 | 34 | 215.0 | 186 | 71 | 62 | 75 | 152 | 14 | 10 | 0 | 0 | 0 | 2.60 |
| 6 | Adam Wainwright | STL | 34 | 34 | 233.0 | 216 | 75 | 68 | 66 | 212 | 19 | 8 | 0 | 0 | 0 | 2.63 |
| 7 | Roy Halladay | TOR | 32 | 32 | 239.0 | 234 | 82 | 74 | 35 | 208 | 17 | 10 | 0 | 0 | 0 | 2.79 |
| 8 | Clayton Kershaw | LAD | 31 | 30 | 171.0 | 119 | 55 | 53 | 91 | 185 | 8 | 8 | 0 | 0 | 0 | 2.79 |
| 9 | Javier Vazquez | ATL | 32 | 32 | 219.1 | 181 | 75 | 70 | 44 | 238 | 15 | 10 | 0 | 0 | 0 | 2.87 |
| 10 | Matt Cain | SFO | 33 | 33 | 217.2 | 184 | 73 | 70 | 73 | 171 | 14 | 8 | 0 | 0 | 0 | 2.89 |
| Rank | JUGADOR | EQUIPO | JJ | JI | EL | H | D | CL | BB | P | G | P | SALV | HLD | BLSV | EFE |
| 11 | J.A. Happ | PHI | 35 | 23 | 166.0 | 149 | 55 | 54 | 56 | 119 | 12 | 4 | 0 | 0 | 0 | 2.93 |
| 12 | Wandy Rodriguez | HOU | 33 | 33 | 205.2 | 192 | 77 | 69 | 63 | 193 | 14 | 12 | 0 | 0 | 0 | 3.02 |
| 13 | Randy Wells | CHC | 27 | 27 | 165.1 | 165 | 67 | 56 | 46 | 104 | 12 | 10 | 0 | 0 | 0 | 3.05 |
| 14 | Ted Lilly | CHC | 27 | 27 | 177.0 | 151 | 66 | 61 | 36 | 151 | 12 | 9 | 0 | 0 | 0 | 3.10 |
| 15 | Johan Santana | NYM | 25 | 25 | 166.2 | 156 | 67 | 58 | 46 | 146 | 13 | 9 | 0 | 0 | 0 | 3.13 |
| 16 | Dan Haren | ARI | 33 | 33 | 229.1 | 192 | 83 | 80 | 38 | 223 | 14 | 10 | 0 | 0 | 0 | 3.14 |
| 17 | Cliff Lee | CLE/PHI | 34 | 34 | 231.2 | 245 | 88 | 83 | 43 | 181 | 14 | 13 | 0 | 0 | 0 | 3.22 |
| 18 | Josh Johnson | FLA | 33 | 33 | 209.0 | 184 | 77 | 75 | 58 | 191 | 15 | 5 | 0 | 0 | 0 | 3.23 |
| 19 | Randy Wolf | LAD | 34 | 34 | 214.1 | 178 | 81 | 77 | 58 | 160 | 11 | 7 | 0 | 0 | 0 | 3.23 |
| 20 | CC Sabathia | NYY | 34 | 34 | 230.0 | 197 | 96 | 86 | 67 | 197 | 19 | 8 | 0 | 0 | 0 | 3.37 |
| Rank | JUGADOR | EQUIPO | JJ | JI | EL | H | D | CL | BB | P | G | P | SALV | HLD | BLSV | EFE |
| 21 | Jon Lester | BOS | 32 | 32 | 203.1 | 186 | 80 | 77 | 64 | 225 | 15 | 8 | 0 | 0 | 0 | 3.41 |
| 22 | Justin Verlander | DET | 35 | 35 | 240.0 | 219 | 99 | 92 | 63 | 269 | 19 | 9 | 0 | 0 | 0 | 3.45 |
| 23 | Ubaldo Jimenez | COL | 33 | 33 | 218.0 | 183 | 87 | 84 | 85 | 198 | 15 | 12 | 0 | 0 | 0 | 3.47 |
| 24 | Joel Pineiro | STL | 32 | 32 | 214.0 | 218 | 94 | 83 | 27 | 105 | 15 | 12 | 0 | 0 | 0 | 3.49 |
| 25 | Edwin Jackson | DET | 33 | 33 | 214.0 | 200 | 93 | 86 | 70 | 161 | 13 | 9 | 0 | 0 | 0 | 3.62 |
| 26 | Ryan Dempster | CHC | 31 | 31 | 200.0 | 196 | 94 | 81 | 65 | 172 | 11 | 9 | 0 | 0 | 0 | 3.65 |
| 27 | Kevin Millwood | TEX | 31 | 31 | 198.2 | 195 | 88 | 81 | 71 | 123 | 13 | 10 | 0 | 0 | 0 | 3.67 |
| 28 | Yovani Gallardo | MIL | 30 | 30 | 185.2 | 150 | 78 | 77 | 94 | 204 | 13 | 12 | 0 | 0 | 0 | 3.73 |
| 29 | Jered Weaver | LAA | 33 | 33 | 211.0 | 196 | 91 | 88 | 66 | 174 | 16 | 8 | 0 | 0 | 0 | 3.75 |
| 30 | Carlos Zambrano | CHC | 28 | 28 | 169.1 | 155 | 78 | 71 | 78 | 152 | 9 | 7 | 0 | 0 | 0 | 3.77 |
| Rank | JUGADOR | EQUIPO | JJ | JI | EL | H | D | CL | BB | P | G | P | SALV | HLD | BLSV | EFE |
| 31 | John Danks | CHW | 32 | 32 | 200.1 | 184 | 89 | 84 | 73 | 149 | 13 | 11 | 0 | 0 | 0 | 3.77 |
| 32 | Jarrod Washburn | DET/SEA | 28 | 28 | 176.0 | 160 | 77 | 74 | 49 | 100 | 9 | 9 | 0 | 0 | 0 | 3.78 |
| 33 | John Lackey | LAA | 27 | 27 | 176.1 | 177 | 84 | 75 | 47 | 139 | 11 | 8 | 0 | 0 | 0 | 3.83 |
| 34 | Mark Buehrle | CHW | 33 | 33 | 213.1 | 222 | 97 | 91 | 45 | 105 | 13 | 10 | 0 | 0 | 0 | 3.84 |
| 35 | Bronson Arroyo | CIN | 33 | 33 | 220.1 | 214 | 101 | 94 | 65 | 127 | 15 | 13 | 0 | 0 | 0 | 3.84 |
| 36 | Josh Beckett | BOS | 32 | 32 | 212.1 | 198 | 99 | 91 | 55 | 199 | 17 | 6 | 0 | 0 | 0 | 3.86 |
| 37 | John Lannan | WAS | 33 | 33 | 206.1 | 210 | 100 | 89 | 68 | 89 | 9 | 13 | 0 | 0 | 0 | 3.88 |
| 38 | Kevin Correia | SDG | 33 | 33 | 198.0 | 194 | 92 | 86 | 64 | 142 | 12 | 11 | 0 | 0 | 0 | 3.91 |
| 39 | Ross Ohlendorf | PIT | 29 | 29 | 176.2 | 165 | 80 | 77 | 53 | 109 | 11 | 10 | 0 | 0 | 0 | 3.92 |
| 40 | Jeff Niemann | TAM | 31 | 30 | 180.2 | 185 | 84 | 79 | 59 | 125 | 13 | 6 | 0 | 0 | 0 | 3.94 |
Data provided by Elias Sports Bureau