| Pitcheo | ||||||||||||||||
| Rank | JUGADOR | EQUIPO | JJ | JI | EL | H | D | CL | BB | P | G | P | SALV | HLD | BLSV | EFE |
| 1 | Daniel Bard | BOS | 2 | 0 | 3.0 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 0 | 1 | 0 | 0.00 |
| 2 | Mariano Rivera | NYY | 12 | 0 | 16.0 | 10 | 1 | 1 | 5 | 14 | 0 | 0 | 5 | 0 | 0 | 0.56 |
| 3 | Adam Wainwright | STL | 1 | 1 | 8.0 | 3 | 1 | 1 | 1 | 7 | 0 | 0 | 0 | 0 | 0 | 1.13 |
| 4 | Cliff Lee | PHI | 5 | 5 | 40.1 | 27 | 10 | 7 | 6 | 33 | 4 | 0 | 0 | 0 | 0 | 1.56 |
| 5 | Nick Blackburn | MIN | 1 | 1 | 5.2 | 3 | 1 | 1 | 2 | 3 | 0 | 0 | 0 | 0 | 0 | 1.59 |
| 6 | CC Sabathia | NYY | 5 | 5 | 36.1 | 28 | 9 | 8 | 9 | 32 | 3 | 1 | 0 | 0 | 0 | 1.98 |
| 7 | John Lackey | LAA | 3 | 3 | 19.2 | 19 | 7 | 5 | 7 | 14 | 1 | 1 | 0 | 0 | 0 | 2.29 |
| 8 | Carl Pavano | MIN | 1 | 1 | 7.0 | 5 | 2 | 2 | 0 | 9 | 0 | 1 | 0 | 0 | 0 | 2.57 |
| 9 | Jered Weaver | LAA | 4 | 2 | 13.2 | 7 | 4 | 4 | 6 | 14 | 1 | 0 | 0 | 1 | 0 | 2.63 |
| 10 | Andy Pettitte | NYY | 5 | 5 | 30.2 | 26 | 12 | 12 | 11 | 25 | 4 | 0 | 0 | 0 | 0 | 3.52 |
| Rank | JUGADOR | EQUIPO | JJ | JI | EL | H | D | CL | BB | P | G | P | SALV | HLD | BLSV | EFE |
| 11 | Clay Buchholz | BOS | 1 | 1 | 5.0 | 6 | 2 | 2 | 1 | 3 | 0 | 0 | 0 | 0 | 0 | 3.60 |
| 12 | Vicente Padilla | LAD | 3 | 3 | 17.1 | 12 | 7 | 7 | 4 | 13 | 1 | 1 | 0 | 0 | 0 | 3.63 |
| 13 | Pedro Martinez | PHI | 3 | 3 | 17.0 | 11 | 7 | 7 | 4 | 16 | 0 | 2 | 0 | 0 | 0 | 3.71 |
| 14 | Joe Saunders | LAA | 2 | 2 | 10.1 | 13 | 5 | 5 | 6 | 5 | 0 | 1 | 0 | 0 | 0 | 4.35 |
| 15 | Jon Lester | BOS | 1 | 1 | 6.0 | 4 | 3 | 3 | 4 | 5 | 0 | 1 | 0 | 0 | 0 | 4.50 |
| 16 | Randy Wolf | LAD | 2 | 2 | 9.0 | 10 | 5 | 5 | 7 | 4 | 0 | 0 | 0 | 0 | 0 | 5.00 |
| 17 | Joe Blanton | PHI | 4 | 2 | 15.2 | 15 | 10 | 9 | 4 | 10 | 0 | 0 | 0 | 0 | 0 | 5.17 |
| 18 | Ubaldo Jimenez | COL | 2 | 2 | 12.0 | 15 | 7 | 7 | 3 | 11 | 0 | 1 | 0 | 0 | 0 | 5.25 |
| 19 | A.J. Burnett | NYY | 5 | 5 | 27.1 | 22 | 16 | 16 | 16 | 24 | 1 | 1 | 0 | 0 | 0 | 5.27 |
| 20 | Josh Beckett | BOS | 1 | 1 | 6.2 | 5 | 4 | 4 | 1 | 3 | 0 | 1 | 0 | 0 | 0 | 5.40 |
| Rank | JUGADOR | EQUIPO | JJ | JI | EL | H | D | CL | BB | P | G | P | SALV | HLD | BLSV | EFE |
| Aaron Cook | COL | 1 | 1 | 5.0 | 7 | 3 | 3 | 2 | 4 | 1 | 0 | 0 | 0 | 0 | 5.40 | |
| 22 | Clayton Kershaw | LAD | 3 | 2 | 13.1 | 14 | 9 | 9 | 7 | 10 | 0 | 1 | 0 | 0 | 0 | 6.08 |
| 23 | Chris Carpenter | STL | 1 | 1 | 5.0 | 9 | 4 | 4 | 4 | 3 | 0 | 1 | 0 | 0 | 0 | 7.20 |
| 24 | Cole Hamels | PHI | 4 | 4 | 19.0 | 25 | 16 | 16 | 4 | 15 | 1 | 2 | 0 | 0 | 0 | 7.58 |
| 25 | Scott Kazmir | LAA | 3 | 2 | 10.2 | 11 | 10 | 9 | 8 | 4 | 0 | 1 | 0 | 0 | 0 | 7.59 |
| 26 | Joel Pineiro | STL | 1 | 1 | 4.0 | 7 | 4 | 4 | 0 | 3 | 0 | 1 | 0 | 0 | 0 | 9.00 |
| 27 | Brian Duensing | MIN | 1 | 1 | 4.2 | 7 | 5 | 5 | 1 | 3 | 0 | 1 | 0 | 0 | 0 | 9.64 |
Data provided by Elias Sports Bureau