Luca Rossettini's stoppage-time goal boosted Bologna to an unlikely 1-0 victory over Genoa at the Stadio Luigi Ferraris.
The Grifone dominated throughout but were thwarted by Bologna goalkeeper Antonio Mirante, who made countless saves to regularly frustrate the likes of Serge Gakpe and Goran Pandev.
Genoa's dominance finally waned when substitute Diego Perotti was dismissed for elbowing Amadou Diawara in the 80th minute, and right-back Rossettini made best use of the extra space on the pitch.
One minute into time added on, he rose above Diego Laxalt to head home at a corner. Diawara was subsequently sent off for dissent at the death, but Bologna had done enough.
ends